The G671V variant of MRP1/ABCC1 links doxorubicin-induced acute cardiac toxicity to disposition of the glutathione conjugate of 4-hydroxy-2-trans-nonenal.

doi:10.1097/FPC.0b013e328350e270

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The G671V variant of MRP1/ABCC1 links doxorubicin-induced acute cardiac toxicity to disposition of the glutathione conjugate of 4-hydroxy-2-trans-nonenal.

Pharmacogenetics and genomics - 1 Apr 2012

Jungsuwadee Paiboon, Zhao Tianyong, Stolarczyk Elzbieta I, Paumi Christian M, Butterfield D Allan, St Clair Daret K, Vore Mary

Abstract excerpt

OBJECTIVE: Doxorubicin-induced acute cardiotoxicity is associated with the Gly671Val (G671V; rs45511401) variant of multidrug resistance-associated protein 1 (MRP1). Doxorubicin redox cycling causes lipid peroxidation and generation of the reactive electrophile, 4-hydroxy-2-trans-nonenal (HNE). Glutathione forms conjugates with HNE, yielding an MRP1 substrate, GS-HNE, whose intracellular accumulation can cause...

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PMID: 22293538
DOI: 10.1097/FPC.0b013e328350e270
PMCID: PMC3308135

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ABCC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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