Article
Defective somite patterning in mouse embryos with reduced levels of Tbx6.
Development (Cambridge, England) - 1 Apr 2003
White Phillip H, Farkas Deborah R, McFadden Erin E, Chapman Deborah L
Abstract excerpt
During vertebrate embryogenesis, paraxial mesoderm gives rise to somites, which subsequently develop into the dermis, skeletal muscle, ribs and vertebrae of the adult. Mutations that disrupt the patterning of individual somites have dramatic effects on these tissues, including fusions of the ribs and vertebrae. The T-box transcription factor, Tbx6, is expressed in the paraxial mesoderm but is downregulated as...
Topics
- Animals
- Body Patterning
- Cytokines
- Embryo, Mammalian
- Humans
- In Situ Hybridization
- Intracellular Signaling Peptides and Proteins
- Membrane Proteins
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Morphogenesis
- Mutation
- Myogenin
- Phenotype
- Proteins
- Ribs
- Somites