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Article

Functionally distinct roles for T and Tbx6 during mouse development.

Biology open - 27 Aug 2020

Wehn Amy K, Farkas Deborah R, Sedlock Carly E, Subedi Dibya, Chapman Deborah L

Abstract excerpt

The mouse T-box transcription factors T and Tbx6 are co-expressed in the primitive streak and have unique domains of expression; T is expressed in the notochord, while Tbx6 is expressed in the presomitic mesoderm. T-box factors are related through a shared DNA binding domain, the T-domain, and can therefore bind to similar DNA sequences at least in vitro We investigated the functional similarities and differences...

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Share to Brachyury Protein
Share to Embryo, Mammalian
Share to Embryonic Development

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enhancer Elements, Genetic

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Source

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Identifiers

PMID: 32855167
DOI: 10.1242/bio.054692
PMCID: PMC7473639

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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