Article
The mouse rib-vertebrae mutation is a hypomorphic Tbx6 allele.
Mechanisms of development - 1 Dec 2002
Watabe-Rudolph Masami, Schlautmann Nicole, Papaioannou Virginia E, Gossler Achim
Abstract excerpt
Rib-vertebrae (rv) is an autosomal recessive mutation in mouse that affects somite formation, morphology, and patterning. Expression of Notch pathway components is affected in the paraxial mesoderm of rv mutant embryos, and rv and a null allele of the Notch ligand delta1 show non-allelic non-complementation. By fine genetic mapping and complementation testing we have identified Tbx6, a gene essential for paraxial...
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