Article
A worldwide survey of haplotype variation and linkage disequilibrium in the human genome.
Nature genetics - 1 Nov 2006
Conrad Donald F, Jakobsson Mattias, Coop Graham, Wen Xiaoquan, Wall Jeffrey D, Rosenberg Noah A, Pritchard Jonathan K
Abstract excerpt
Recent genomic surveys have produced high-resolution haplotype information, but only in a small number of human populations. We report haplotype structure across 12 Mb of DNA sequence in 927 individuals representing 52 populations. The geographic distribution of haplotypes reflects human history, with a loss of haplotype diversity as distance increases from Africa. Although the extent of linkage disequilibrium...
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