Article
Telomeres and the DNA damage response: why the fox is guarding the henhouse.
DNA repair - 1 Jan 2000
Maser Richard S, DePinho Ronald A
Abstract excerpt
DNA double strand breaks (DSBs) are repaired by an extensive network of proteins that recognize damaged DNA and catalyze its repair. By virtue of their similarity, the normal ends of linear chromosomes and internal DNA DSBs are both potential substrates for DSB repair enzymes. Thus, telomeres, specialized nucleo-protein complexes that cap chromosomal ends, serve a critical function to differentiate themselves...
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