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Article

A novel action of terpendole E on the motor activity of mitotic Kinesin Eg5.

Chemistry & biology - 1 Feb 2003

Nakazawa Junko, Yajima Junichiro, Usui Takeo, Ueki Masashi, Takatsuki Akira, Imoto Masaya, Toyoshima Yoko Y, Osada Hiroyuki

Abstract excerpt

To reveal the mechanism of mitosis, the development of M phase-specific inhibitors is an important strategy. We have been screening microbial products to find specific M phase inhibitors that do not directly target tubulins, and rediscovered terpendole E (TerE) as a novel Eg5 inhibitor. TerE did not affect microtubule integrity in interphase, but induced formation of a monoastral spindle in M phase. TerE...

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Identifiers

PMID: 12618185
DOI: 10.1016/s1074-5521(03)00020-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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