Article
Iejimalides show anti-osteoclast activity via V-ATPase inhibition.
Bioscience, biotechnology, and biochemistry - 1 Jun 2006
Kazami Sayaka, Muroi Makoto, Kawatani Makoto, Kubota Takaaki, Usui Takeo, Kobayashi Jun'ichi, Osada Hiroyuki
Abstract excerpt
Iejimalides (IEJLs), 24-membered macrolides, are potent antitumor compounds, but their molecular targets remain to be revealed. In the course of screening, we identified IEJLs as potent osteoclast inhibitors. Since it is known that osteoclasts are sensitive to vacuolar H(+)-ATPase (V-ATPase) inhibitor, we investigated the effect of IEJLs on V-ATPases. IEJLs inhibited the V-ATPases of both mammalian and yeast...
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