Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Isolation, biology and chemistry of the disorazoles: new anti-cancer macrodiolides

1 Jan 2009

Abstract excerpt

Covering: 1994 to 2008. The disorazoles comprise a family of 29 closely related macrocyclic polyketides isolated in 1994 from the fermentation broth of the gliding myxobacterium Sorangium cellulosum. Disorazoles A1, E and C1 have shown exceptional biological activites toward inhibiting the proliferation of human cancer cell lines in picomolar and nanomolar concentrations through the disruption of microtubule...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer therapeutics and mechanisms
Share to Cancer Treatment and Pharmacology
Share to Synthesis and biological activity

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19387496
DOI: 10.1039/b813799b

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Isolation, biology and chemistry of the disorazoles: new anti-cancer macrodiolidesPMID 19387496Read ↗

The cryptophycins: Their synthesis and anticancer activitySemantic proximity Read ↗

Microbial natural products: molecular blueprints for antitumor drugsSemantic proximity Read ↗

Marine Mollusk‐Derived Agents with Antiproliferative Activity as Promising Anticancer Agents to Overcome Chemotherapy ResistanceSemantic proximity Read ↗

Myxobacterial secondary metabolites: bioactivities and modes-of-actionSemantic proximity Read ↗

Unlocking the Drug Potential of the Bryostatin Family: Recent Advances in Product Synthesis and Biomedical ApplicationsSemantic proximity Read ↗

Fungal bioactive macrolidesSemantic proximity Read ↗

Targeting Microtubules by Natural Agents for Cancer TherapySemantic proximity Read ↗

Review on Abyssomicins: Inhibitors of the Chorismate Pathway and Folate BiosynthesisSemantic proximity Read ↗

Miuraenamides A and B, Novel Antimicrobial Cyclic Depsipeptides from a New Slightly Halophilic Myxobacterium: Taxonomy, Production, and Biological PropertiesSemantic proximity Read ↗

Pipeline of anti‐Mycobacterium abscessussmall molecules: Repurposable drugs and promising novel chemical entitiesSemantic proximity Read ↗

Targeting and extending the eukaryotic druggable genome with natural products: cytoskeletal targets of natural productsSemantic proximity Read ↗

Structure elucidation and antitumour activity of a new macrolactam produced by marine-derived actinomycete <i>Micromonospora</i> sp. FIM05328Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.