Article
Discovery and biochemical characterization of selective ATP competitive inhibitors of the human mitotic kinesin KSP.
Archives of biochemistry and biophysics - 15 Jan 2008
Rickert Keith W, Schaber Michael, Torrent Maricel, Neilson Lou Anne, Tasber Edward S, Garbaccio Robert, Coleman Paul J, Harvey Diane, Zhang Yun, Yang Yi, Marshall Gary, Lee Ling, Walsh Eileen S, Hamilton Kelly, Buser Carolyn A
Abstract excerpt
The kinesin spindle protein (KSP, also known as Eg5) is essential for the proper separation of spindle poles during mitosis, and inhibition results in mitotic arrest and the formation of characteristic monoaster spindles. Several distinct classes of KSP inhibitors have been described previously i...
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