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Article

Identification of a key determinant of hepatitis C virus cell culture adaptation in domain II of NS3 helicase.

The Journal of biological chemistry - 9 May 2003

Grobler Jay A, Markel Eric J, Fay John F, Graham Donald J, Simcoe Amy L, Ludmerer Steve W, Murray Edward M, Migliaccio Giovanni, Flores Osvaldo A

Abstract excerpt

Efficient replication of hepatitis C virus (HCV) replicons in cell culture is associated with specific sequences not generally observed in vivo. These cell culture adaptive mutations dramatically increase the frequency with which replication is established in vitro. However, replicons derived from HCV isolates that have been shown to replicate in chimpanzees do not replicate in cell culture even when these...

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PMID: 12615931
DOI: 10.1074/jbc.M212602200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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