Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Enhancement of hepatitis C virus RNA replication by cell culture-adaptive mutations.

Journal of virology - 1 May 2001

Krieger N, Lohmann V, Bartenschlager R

Abstract excerpt

Studies of the Hepatitis C virus (HCV) replication cycle have been made possible with the development of subgenomic selectable RNAs that replicate autonomously in cultured cells. In these replicons the region encoding the HCV structural proteins was replaced by the neomycin phosphotransferase gene, allowing the selection of transfected cells that support high-level replication of these RNAs. Subsequent analyses...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptation, Physiological
Share to Cell Culture Techniques
Share to Genes, Reporter

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hepacivirus

Share to Luciferases

Share to Replicon

Share to Viral Nonstructural Proteins

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 11312331
DOI: 10.1128/JVI.75.10.4614-4624.2001
PMCID: PMC114214

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Enhancement of hepatitis C virus RNA replication by cell culture-adaptive mutations.PMID 11312331Read ↗

Mutations in hepatitis C virus RNAs conferring cell culture adaptation.Semantic proximity Read ↗

Viral and Cellular Determinants of Hepatitis C Virus RNA Replication in Cell CultureSemantic proximity Read ↗

Efficient initiation of HCV RNA replication in cell culture.Semantic proximity Read ↗

Replication of hepatitis C virus genotype 3a in cultured cells.Semantic proximity Read ↗

Hepatitis C virus cell culture adaptive mutations enhance cell culture propagation by multiple mechanisms but boost antiviral responses in primary human hepatocytesSemantic proximity Read ↗

Unraveling the dynamics of hepatitis C virus adaptive mutations and their impact on antiviral responses in primary human hepatocytes.Semantic proximity Read ↗

Natural selection of adaptive mutations in non-structural genes increases trans-encapsidation of hepatitis C virus replicons lacking envelope protein genes.Semantic proximity Read ↗

Development of robust genotype 1a hepatitis C replicons harboring adaptive mutations for facilitating the antiviral drug discovery and study of virus replication.Semantic proximity Read ↗

Efficient replication of genotype 3a and 4a hepatitis C virus replicons in human hepatoma cells.Semantic proximity Read ↗

Novel cell culture-adapted genotype 2a hepatitis C virus infectious clone.Semantic proximity Read ↗

Cell culture-adaptive mutations promote viral protein-protein interactions and morphogenesis of infectious hepatitis C virus.Semantic proximity Read ↗

Replication-competent chimeric hepatitis C virus subgenomic replicons.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.