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Viral and Cellular Determinants of Hepatitis C Virus RNA Replication in Cell Culture

12 Feb 2003

Abstract excerpt

Studies on the replication of hepatitis C virus (HCV) have been facilitated by the development of selectable subgenomic replicons replicating in the human hepatoma cell line Huh-7 at a surprisingly high level. Analysis of the replicon population in selected cells revealed the occurrence of cell culture-adaptive mutations that enhance RNA replication substantially. To gain a better understanding of HCV cell...

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PMID: 12584326
DOI: 10.1128/jvi.77.5.3007-3019.2003

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