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Article

Stability and Cu(II) binding of prion protein variants related to inherited human prion diseases.

Biophysical journal - 1 Mar 2003

Cereghetti Grazia M, Schweiger Arthur, Glockshuber Rudi, Van Doorslaer Sabine

Abstract excerpt

All inherited forms of human prion diseases are linked with mutations in the prion protein (PrP) gene. Here we have investigated the stability and Cu(II) binding properties of three recombinant variants of murine full-length PrP(23-231)-containing destabilizing point mutations that are associated with human Gerstmann-Sträussler-Scheinker disease (F198S), Creutzfeld-Jakob disease (E200K), and fatal familial...

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Identifiers

PMID: 12609901
DOI: 10.1016/S0006-3495(03)75007-3
PMCID: PMC1302768

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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