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Article

Distinct effects of mutations on biophysical properties of human prion protein monomers and oligomers.

Acta biochimica et biophysica Sinica - 1 Nov 2016

Yu Yuanhui, Yu Ziyao, Zheng Zhen, Wang Huilin, Wu Xueji, Guo Chenyun, Lin Donghai

Abstract excerpt

Prion diseases are a group of fatal neurodegenerative illnesses, resulting from the conformational conversion of the cellular prion protein (PrPC) into a misfolded form (PrPSc). The formation of neurotoxic soluble prion protein oligomer (PrPO) is regarded as a key step in the development of prion diseases. About 10%-15% of human prion diseases are caused by mutations in the prion protein gene; however, the...

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PMID: 27649893
DOI: 10.1093/abbs/gmw094

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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