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Article

Biophysical characterization of oligomerization and fibrillization of the G131V pathogenic mutant of human prion protein.

Acta biochimica et biophysica Sinica - 13 Dec 2019

Zhang Meilan, Zhang Haoran, Yao Hongwei, Guo Chenyun, Lin Donghai

Abstract excerpt

The pathogenesis of fatal neurodegenerative prion diseases is closely associated with the conversion of α-helix-rich cellular prion protein into β-sheet-rich scrapie form. Pathogenic point mutations of prion proteins usually promote the conformational conversion and trigger inherited prion diseases. The G131V mutation of human prion protein (HuPrP) was identified to be involved in Gerstmann-Sträussler-Scheinker...

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PMID: 31735962
DOI: 10.1093/abbs/gmz124

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