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Article

Methionine oxidation accelerates the aggregation and enhances the neurotoxicity of the D178N variant of the human prion protein.

Biochimica et biophysica acta - 1 Dec 2014

Feng Boya, Wang Zonglin, Liu Ting, Jin Rui, Wang Shaobo, Wang Wei, Xiao Gengfu, Zhou Zheng

Abstract excerpt

The D178N mutation of the prion protein (PrP) results in the hereditary prion disease fatal familial insomnia (FFI). Little is known regarding the effects of methionine oxidation on the pathogenesis of D178N-associated FFI. In the present study, we found that the D178N variant was more susceptible to oxidation than wild-type PrP, as indicated by reverse-phase high performance liquid chromatography (RP-HPLC) and...

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PMID: 25281825
DOI: 10.1016/j.bbadis.2014.09.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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