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Article

Impact of methionine oxidation as an initial event on the pathway of human prion protein conversion.

Prion - 1 Jan 2000

Elmallah Mohammed I Y, Borgmeyer Uwe, Betzel Christian, Redecke Lars

Abstract excerpt

Prion diseases comprise a group of fatal neurodegenerative disorders characterized by the autocatalytic conversion of the cellular prion protein PrP(C) into the infectious misfolded isoform PrP(Sc). Increasing evidence supports a specific role of oxidative stress in the onset of pathogenesis. Although the associated molecular mechanisms remain to be elucidated in detail, several studies currently suggest that...

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Identifiers

PMID: 24121542
DOI: 10.4161/pri.26745
PMCID: PMC4134345

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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