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Article

Structural rearrangements at physiological pH: nuclear magnetic resonance insights from the V210I human prion protein mutant.

Biochemistry - 25 Sept 2012

Biljan Ivana, Ilc Gregor, Giachin Gabriele, Plavec Janez, Legname Giuseppe

Abstract excerpt

A major focus in prion structural biology studies is unraveling the molecular mechanism leading to the structural conversion of PrP(C) to its pathological form, PrP(Sc). In our recent studies, we attempted to understand the early events of the conformational changes leading to PrP(Sc) using as investigative tools point mutations clustered in the open reading frame of the human PrP gene and linked to genetic forms...

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PMID: 22947063
DOI: 10.1021/bi3009856

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