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Article

Toward the molecular basis of inherited prion diseases: NMR structure of the human prion protein with V210I mutation.

Journal of molecular biology - 30 Sept 2011

Biljan Ivana, Ilc Gregor, Giachin Gabriele, Raspadori Andrea, Zhukov Igor, Plavec Janez, Legname Giuseppe

Abstract excerpt

The development of transmissible spongiform encephalopathies (TSEs) is associated with the conversion of the cellular prion protein (PrP(C)) into a misfolded, pathogenic isoform (PrP(Sc)). Spontaneous generation of PrP(Sc) in inherited forms of disease is caused by mutations in gene coding for PrP (PRNP). In this work, we describe the NMR solution-state structure of the truncated recombinant human PrP (HuPrP)...

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Identifiers

PMID: 21839748
DOI: 10.1016/j.jmb.2011.07.067

Genes

PRNP

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