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Article

NMR structure of the human prion protein with the pathological Q212P mutation reveals unique structural features.

PloS one - 22 Jul 2010

Ilc Gregor, Giachin Gabriele, Jaremko Mariusz, Jaremko Łukasz, Benetti Federico, Plavec Janez, Zhukov Igor, Legname Giuseppe

Abstract excerpt

Prion diseases are fatal neurodegenerative disorders caused by an aberrant accumulation of the misfolded cellular prion protein (PrP(C)) conformer, denoted as infectious scrapie isoform or PrP(Sc). In inherited human prion diseases, mutations in the open reading frame of the PrP gene (PRNP) are hypothesized to favor spontaneous generation of PrP(Sc) in specific brain regions leading to neuronal cell degeneration...

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Identifiers

PMID: 20661422
DOI: 10.1371/journal.pone.0011715
PMCID: PMC2908606

Genes

GSS
PRNP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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