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Article

Human CHD1 is required for early DNA-damage signaling and is uniquely regulated by its N terminus

13 Feb 2018

Abstract excerpt

CHD1 is a conserved chromatin remodeling enzyme required for development and linked to prostate cancer in adults, yet its role in human cells is poorly understood. Here, we show that targeted disruption of the CHD1 gene in human cells leads to a defect in early double-strand break (DSB) repair via homologous recombination (HR), resulting in hypersensitivity to ionizing radiation as well as PARP and PTEN...

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PMID: 29529298
DOI: 10.1093/nar/gky128

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