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Article

MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways.

Nature - 27 Feb 2003

Lou Zhenkun, Minter-Dykhouse Katherine, Wu Xianglin, Chen Junjie

Abstract excerpt

Forkhead-homology-associated (FHA) domains function as protein-protein modules that recognize phosphorylated serine/threonine motifs. Interactions between FHA domains and phosphorylated proteins are thought to have essential roles in the transduction of DNA damage signals; however, it is unclear how FHA-domain-containing proteins participate in mammalian DNA damage responses. Here we report that a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12607004
DOI: 10.1038/nature01447

Genes

MDC1
ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways.PMID 12607004Read ↗

The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediatorSemantic proximity Read ↗

MDC1 is a mediator of the mammalian DNA damage checkpoint.Semantic proximity Read ↗

The hCds1 (Chk2)-FHA domain is essential for a chain of phosphorylation events on hCds1 that is induced by ionizing radiation.Semantic proximity Read ↗

Structural mechanism of the phosphorylation-dependent dimerization of the MDC1 forkhead-associated domain.Semantic proximity Read ↗

Roles for MDC1 in cancer development and treatment.Semantic proximity Read ↗

Functional defects of cancer-associated MDC1 mutations in DNA damage repair.Semantic proximity Read ↗

A phospho-proteomic screen identifies substrates of the checkpoint kinase Chk1Semantic proximity Read ↗

Structural and functional versatility of the FHA domain in DNA-damage signaling by the tumor suppressor kinase Chk2.Semantic proximity Read ↗

TTK/hMps1 participates in the regulation of DNA damage checkpoint response by phosphorylating CHK2 on threonine 68.Semantic proximity Read ↗

Dimerization Mediated by a Divergent Forkhead-associated Domain Is Essential for the DNA Damage and Spindle Functions of Fission Yeast Mdb1.Semantic proximity Read ↗

Role of the N-terminal forkhead-associated domain in the cell cycle checkpoint function of the Rad53 kinase.Semantic proximity Read ↗

Chk1 and Chk2 kinases in checkpoint control and cancer.Semantic proximity Read ↗

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