Article
Silencing of glycopeptide resistance in Enterococcus faecalis BM4405 by novobiocin.
Antimicrobial agents and chemotherapy - 1 Apr 2005
Patiño Lorena Abadía, Chippaux Marc, Courvalin Patrice, Périchon Bruno
Abstract excerpt
Enterococcus faecalis BM4405-1, a susceptible derivative of the VanE-type vancomycin-resistant E. faecalis strain BM4405, was obtained after growth in the presence of novobiocin, an inhibitor of the GyrB subunit of DNA gyrase. In contrast to findings for BM4405, UDP-MurNAc-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala (pentapeptide[D-Ala]) was the only peptidoglycan precursor found in BM4405-1, and no VanXY(E)...
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