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Influence of age and cytochrome P450 2C9 genotype on the steady-state disposition of diclofenac and celecoxib.

Clinical pharmacokinetics - 1 Jan 2003

Brenner Stefanie S, Herrlinger Charlotte, Dilger Karin, Mürdter Thomas E, Hofmann Ute, Marx Claudia, Klotz Ulrich

Abstract excerpt

OBJECTIVE: To analyse the influence of age and cytochrome P450 (CYP) 2C9 genotype on the steady-state disposition of the standard NSAID diclofenac and the new COX-2 selective inhibitor celecoxib, both of which are metabolised by the polymorphically expressed CYP2C9. DESIGN: Double-blind randomised crossover study under steady-state conditions. SUBJECTS: 12 young (age 32 +/- 5 years, bodyweight 71 +/- 12kg; mean...

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PMID: 12603175
DOI: 10.2165/00003088-200342030-00003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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