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Interaction of age and CYP2C19 genotypes on voriconazole steady-state trough concentration in Chinese patients.

Pharmacogenetics and genomics - 1 Aug 2024

Du Yin-Xiao, Zhu Ying-Xia, Li Liang, Yang Jing, Chen Xiao-Ping

Abstract excerpt

OBJECTIVES: Both age and CYP2C19 genotypes affect voriconazole plasma concentration; the interaction of age and CYP2C19 genotypes on voriconazole plasma concentration remains unknown. This study aims to investigate the combined effects of age and CYP2C19 genotypes on voriconazole plasma concentration in Chinese patients. METHODS: A total of 480 patients who received voriconazole treatment were recruited....

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PMID: 38747453
DOI: 10.1097/FPC.0000000000000536

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