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Article

Effects of CYP2C9 genetic polymorphisms on the pharmacokinetics of celecoxib and its carboxylic acid metabolite.

Archives of pharmacal research - 1 Mar 2017

Kim Se-Hyung, Kim Do-Hoon, Byeon Ji-Yeong, Kim Young-Hoon, Kim Dong-Hyun, Lim Hye-Jin, Lee Choong-Min, Whang Sang Sup, Choi Chang-Ik, Bae Jung-Woo, Lee Yun Jeong, Jang Choon-Gon, Lee Seok-Yong

Abstract excerpt

Celecoxib, a selective cyclooxygenase (COX)-2 inhibitor, is used for the treatment of rheumatoid arthritis and osteoarthritis. The predominant hepatic metabolism of celecoxib to celecoxib carboxylic acid (CCA) is mediated mainly by CYP2C9. We investigated the effects of the major CYP2C9 genetic variants in Asian populations, CYP2C9*3 and CYP2C9*13, on the pharmacokinetics of celecoxib and its carboxylic acid...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27864660
DOI: 10.1007/s12272-016-0861-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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