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Article

The effect of aging on the relationship between the cytochrome P450 2C19 genotype and omeprazole pharmacokinetics.

Clinical pharmacokinetics - 1 Jan 2005

Ishizawa Yukio, Yasui-Furukori Norio, Takahata Takenori, Sasaki Mutsuo, Tateishi Tomonori

Abstract excerpt

BACKGROUND AND OBJECTIVE: The metabolic activity of cytochrome P450 (CYP) 2C19 is genetically determined, and the pharmacokinetics of omeprazole, a substrate for CYP2C19, are dependent on the CYP2C19 genotype. However, a discrepancy between the CYP2C19 genotype and omeprazole pharmacokinetics was reported in patients with liver disease or advanced cancer. The objective of the present study was to evaluate the...

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Identifiers

PMID: 16231968
DOI: 10.2165/00003088-200544110-00005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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