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The retinoblastoma family of proteins and their regulatory functions in the mammalian cell division cycle

1 Jan 2012

Abstract excerpt

The retinoblastoma (RB) family of proteins are found in organisms as distantly related as humans, plants, and insects. These proteins play a key role in regulating advancement of the cell division cycle from the G1 to S-phases. This is achieved through negative regulation of two important positive regulators of cell cycle entry, E2F transcription factors and cyclin dependent kinases. In growth arrested cells...

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PMID: 22417103
DOI: 10.1186/1747-1028-7-10

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