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Article

Structural basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressor.

Genes & development - 15 Dec 2002

Lee Changwook, Chang Jeong Ho, Lee Hyun Sook, Cho Yunje

Abstract excerpt

Repression of E2F transcription activity by the retinoblastoma (Rb) tumor suppressor through its interaction with the transactivation domain of the E2F transcription factor is one of the central features of G1/S arrest in the mammalian cell cycle. Deregulation of the Rb-E2F interaction results in hyperproliferation, lack of differentiation, and apoptosis, and can lead to cancer. The 2.2-A crystal structure of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12502741
DOI: 10.1101/gad.1046102
PMCID: PMC187509

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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