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Article

Role of the retinoblastoma protein in the pathogenesis of human cancer.

1 Nov 1997

Abstract excerpt

The retinoblastoma gene (RB-1) was originally identified as the gene involved in hereditary retinoblastoma. However, RB-1 mutations are found in a number of common mesenchymal and epithelial malignancies. The retinoblastoma protein (pRB) acts as a transcriptional regulator of genes involved in DNA synthesis and cell-cycle control. In this regard, the functional interaction between pRB and the E2F transcription...

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Identifiers

PMID: 9363859
DOI: 10.1200/jco.1997.15.11.3301

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Source receipt: pubmed, retrieved 7 Sept 2026.

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