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Article

COMT val158met polymorphism and neural pain processing.

PloS one - 1 Jan 2012

Schmahl Christian, Ludäscher Petra, Greffrath Wolfgang, Kraus Anja, Valerius Gabriele, Schulze Thomas G, Treutlein Jens, Rietschel Marcella, Smolka Michael N, Bohus Martin

Abstract excerpt

A functional polymorphism (val158met) of the gene coding for Catechol-O-methyltransferase (COM) has been demonstrated to be related to processing of emotional stimuli. Also, this polymorphism has been found to be associated with pain regulation in healthy subjects. Therefore, we investigated a possible influence of this polymorphism on pain processing in healthy persons as well as in subjects with markedly...

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Identifiers

PMID: 22247753
DOI: 10.1371/journal.pone.0023658
PMCID: PMC3256133

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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