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Article

Conditional deletion of focal adhesion kinase leads to defects in ventricular septation and outflow tract alignment.

Molecular and cellular biology - 1 Aug 2007

Hakim Zeenat S, DiMichele Laura A, Doherty Jason T, Homeister Jonathon W, Beggs Hilary E, Reichardt Louis F, Schwartz Robert J, Brackhan Joseph, Smithies Oliver, Mack Christopher P, Taylor Joan M

Abstract excerpt

To examine a role for focal adhesion kinase (FAK) in cardiac morphogenesis, we generated a line of mice with a conditional deletion of FAK in nkx2-5-expressing cells (herein termed FAKnk mice). FAKnk mice died shortly after birth, likely resulting from a profound subaortic ventricular septal defe...

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Share to Embryo, Mammalian
Share to Focal Adhesion Protein-Tyrosine Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heart Defects, Congenital

Share to Heart Ventricles

Share to Homeobox Protein Nkx-2.5

Share to Morphogenesis

Share to Myocytes, Cardiac

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Source

Open in PubMed Open full text

Identifiers

PMID: 17526730
DOI: 10.1128/MCB.00068-07
PMCID: PMC1952084

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17526730-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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