Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Adjacent phosphorylation sites on GABAA receptor beta subunits determine regulation by cAMP-dependent protein kinase.

Nature neuroscience - 1 May 1998

McDonald B J, Amato A, Connolly C N, Benke D, Moss S J, Smart T G

Abstract excerpt

Activation of cAMP-dependent protein kinase (PKA) can enhance or reduce the function of neuronal GABAA receptors, the major sites of fast synaptic inhibition in the brain. This differential regulation depends on PKA-induced phosphorylation of adjacent conserved sites in the receptor beta subunits. Phosphorylation of beta 3 subunit-containing receptors at S408 and S409 enhanced the GABA-activated response, whereas...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclic AMP
Share to Cyclic AMP-Dependent Protein Kinases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Enzyme Activation

Share to gamma-Aminobutyric Acid

Share to Isomerism

Share to Patch-Clamp Techniques

Share to Phosphorylation

Share to Receptors, GABA-A

Source

Identifiers

PMID: 10195104
DOI: 10.1038/223

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Adjacent phosphorylation sites on GABAA receptor beta subunits determine regulation by cAMP-dependent protein kinase.PMID 10195104Read ↗

A-kinase anchoring protein 79/150 facilitates the phosphorylation of GABA(A) receptors by cAMP-dependent protein kinase via selective interaction with receptor beta subunits.Semantic proximity Read ↗

Beta subunit phosphorylation selectively increases fast desensitization and prolongs deactivation of alpha1beta1gamma2L and alpha1beta3gamma2L GABA(A) receptor currents.Semantic proximity Read ↗

PKA phosphorylation of AMPA receptor subunits controls synaptic trafficking underlying plasticity.Semantic proximity Read ↗

Shisa7 phosphorylation regulates GABAergic transmission and neurodevelopmental behaviorsSemantic proximity Read ↗

The GABAA receptors. From subunits to diverse functions.Semantic proximity Read ↗

Distinct regulation of beta2 and beta3 subunit-containing cerebellar synaptic GABAA receptors by calcium/calmodulin-dependent protein kinase II.Semantic proximity Read ↗

Compromising the phosphodependent regulation of the GABAAR β3 subunit reproduces the core phenotypes of autism spectrum disorders.Semantic proximity Read ↗

Specific subtypes of GABAA receptors mediate phasic and tonic forms of inhibition in hippocampal pyramidal neurons.Semantic proximity Read ↗

Global and local missions of cAMP signaling in neural plasticity, learning, and memorySemantic proximity Read ↗

Effects of isoflurane on gamma-aminobutyric acid type A receptors activated by full and partial agonists.Semantic proximity Read ↗

mGlu4 potentiation of K(2P)2.1 is dependant on C-terminal dephosphorylation.Semantic proximity Read ↗

Structural determinants for antagonist pharmacology that distinguish the rho1 GABAC receptor from GABAA receptors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.