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Article

β2E153 Residue at Loop B of GABAAR Is Involved in Agonist Stabilization and Gating Properties.

International journal of molecular sciences - 20 Dec 2025

Michałowski Michał A, Brzóstowicz Aleksandra, Mozrzymas Jerzy W

Abstract excerpt

γ-Aminobutyric acid type A receptors (GABAARs) are pentameric ligand-gated ion channels mediating fast inhibitory neurotransmission in the mammalian brain. Although recent structural and kinetic studies have advanced understandings regarding their activation mechanisms, the molecular determinants coupling agonist binding to channel gating remain unclear. We investigated the contribution of the β2E153 residue,...

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Identifiers

PMID: 41515928
DOI: 10.3390/ijms27010047
PMCID: PMC12785432

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