Article
PKA phosphorylation of AMPA receptor subunits controls synaptic trafficking underlying plasticity.
Nature neuroscience - 1 Feb 2003
Esteban José A, Shi Song-Hai, Wilson Christopher, Nuriya Mutsuo, Huganir Richard L, Malinow Roberto
Abstract excerpt
The regulated incorporation of AMPA receptors into synapses is important for synaptic plasticity. Here we examine the role of protein kinase A (PKA) in this process. We found that PKA phosphorylation of the AMPA receptor subunits GluR4 and GluR1 directly controlled the synaptic incorporation of AMPA receptors in organotypic slices from rat hippocampus. Activity-driven PKA phosphorylation of GluR4 was necessary...
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