Article

MPZ-T124M mouse model replicates human axonopathy and suggest alteration in axo-glia communication

2022-05-10

Abstract excerpt

Myelin is essential for rapid nerve impulse propagation and axon protection. Accordingly, defects in myelination or myelin maintenance lead to secondary axonal damage and subsequent degeneration. Studies utilizing genetic (CNPase-, MAG-, and PLP-null mice) and naturally occurring neuropathy models suggest that myelinating glia also support axons independently from myelin. Myelin protein zero (MPZ or P0), which is...

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Literature Corpus work: bf5d45f6-485b-56f6-a0bd-befdd32b5243
DOI: 10.1101/2022.05.09.491190

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