Article
A genetic screen identifies genes essential for development of myelinated axons in zebrafish.
Developmental biology - 1 Oct 2006
Pogoda Hans-Martin, Sternheim Nitzan, Lyons David A, Diamond Brianne, Hawkins Thomas A, Woods Ian G, Bhatt Dimple H, Franzini-Armstrong Clara, Dominguez Claudia, Arana Naomi, Jacobs Jennifer, Nix Rebecca, Fetcho Joseph R, Talbot William S
Abstract excerpt
The myelin sheath insulates axons in the vertebrate nervous system, allowing rapid propagation of action potentials via saltatory conduction. Specialized glial cells, termed Schwann cells in the PNS and oligodendrocytes in the CNS, wrap axons to form myelin, a compacted, multilayered sheath comprising specific proteins and lipids. Disruption of myelinated axons causes human diseases, including multiple sclerosis...
Topics
- Animals
- Axons
- Body Patterning
- Central Nervous System
- Embryo, Nonmammalian
- Gene Expression Regulation, Developmental
- Male
- Mutation
- Myelin Sheath
- Nerve Fibers, Myelinated
- Peripheral Nervous System
- Phenotype