Article
Integrin-mediated tyrosine phosphorylation of Shc in T cells is regulated by protein kinase C-dependent phosphorylations of Lck.
Molecular biology of the cell - 1 Feb 2003
Niu Shi, Xie Haichun, Marcantonio Eugene E
Abstract excerpt
Integrin receptor signals are costimulatory for mitogenesis with the T-cell receptor during T-cell activation. A subset of integrin receptors can link to the adapter protein Shc and provide a mitogenic stimulus. Using a combination of genetic and pharmacological approaches, we show herein that integrin signaling to Shc in T cells requires the receptor tyrosine phosphatase CD45, the Src family kinase member Lck,...
Topics
- Antibodies, Monoclonal
- Blotting, Western
- Cell Line
- Cross-Linking Reagents
- Enzyme Inhibitors
- Flow Cytometry
- Gene Expression Regulation, Enzymologic
- Humans
- Integrins
- Jurkat Cells
- Leukocyte Common Antigens
- Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
- Models, Biological