Article
Differential function of PTPalpha and PTPalpha Y789F in T cells and regulation of PTPalpha phosphorylation at Tyr-789 by CD45.
The Journal of biological chemistry - 20 Jul 2007
Maksumova Lola, Wang Yanni, Wong Nelson K Y, Le Hoa T, Pallen Catherine J, Johnson Pauline
Abstract excerpt
CD45 is a major membrane protein tyrosine phosphatase (PTP) expressed in T cells where it regulates the activity of Lck, a Src family kinase important for T cell receptor-mediated activation. PTPalpha is a more widely expressed transmembrane PTP that has been shown to regulate the Src family kinases, Src and Fyn, and is also present in T cells. Here, PTPalpha was phosphorylated at Tyr-789 in CD45(-) T cells but...
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