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Article

Synergy of cAMP and calcium signaling pathways in CFTR regulation.

Proceedings of the National Academy of Sciences of the United States of America - 14 Mar 2017

Bozoky Zoltan, Ahmadi Saumel, Milman Tal, Kim Tae Hun, Du Kai, Di Paola Michelle, Pasyk Stan, Pekhletski Roman, Keller Jacob P, Bear Christine E, Forman-Kay Julie D

Abstract excerpt

Cystic fibrosis results from mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel, leading to defective apical chloride transport. Patients also experience overactivation of inflammatory processes, including increased calcium signaling. Many investigations have described indirect effects of calcium signaling on CFTR or other calcium-activated chloride channels; here, we...

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Share to Calcium Signaling
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28242698
DOI: 10.1073/pnas.1613546114
PMCID: PMC5358358

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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