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Article

Voltage sensors in domains III and IV, but not I and II, are immobilized by Na+ channel fast inactivation.

Neuron - 1 Jan 1999

Cha A, Ruben P C, George A L, Fujimoto E, Bezanilla F

Abstract excerpt

Using site-directed fluorescent labeling, we examined conformational changes in the S4 segment of each domain of the human skeletal muscle sodium channel (hSkM1). The fluorescence signals from S4 segments in domains I and II follow activation and are unaffected as fast inactivation settles. In contrast, the fluorescence signals from S4 segments in domains III and IV show kinetic components during activation and...

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PMID: 10027291
DOI: 10.1016/s0896-6273(00)80680-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Voltage sensors in domains III and IV, but not I and II, are immobilized by Na+ channel fast inactivation.PMID 10027291Read ↗

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