Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The RGS2 gene product from a candidate hypertension allele shows decreased plasma membrane association and inhibition of Gq.

Molecular pharmacology - 1 Apr 2008

Gu Steven, Tirgari Sam, Heximer Scott P

Abstract excerpt

Hypertension is a leading risk factor for the development of cardiovascular disease. Data from human and animal studies suggest that RGS2, a potent inhibitor of G(q) signaling, is important for blood pressure regulation. Several RGS2 mutations in the Japanese population have been found to be associated with hypertension. The product of one of these alleles, R44H, is mutated within the amino terminal amphipathic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to GTP-Binding Protein alpha Subunits, Gq-G11
Share to Hydrophobic and Hydrophilic Interactions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lipid Bilayers

Share to Liposomes

Share to Mutant Proteins

Share to Phospholipids

Share to Protein Structure, Secondary

Share to RGS Proteins

Source

Identifiers

PMID: 18230714
DOI: 10.1124/mol.107.044214

Genes

RGS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The RGS2 gene product from a candidate hypertension allele shows decreased plasma membrane association and inhibition of Gq.PMID 18230714Read ↗

Genetic variations of regulator of G-protein signaling 2 in hypertensive patients and in the general population.Semantic proximity Read ↗

RGS proteins: identifying new GAPs in the understanding of blood pressure regulation and cardiovascular function.Semantic proximity Read ↗

Deregulation of RGS2 in cardiovascular diseasesSemantic proximity Read ↗

Detection of genetic variations of regulator of G-protein signaling 2 in hypertensives by sequencing.Semantic proximity Read ↗

Polymorphisms and haplotypes of the regulator of G protein signaling-2 gene in normotensives and hypertensives.Semantic proximity Read ↗

Association of genetic variations of regulator of G-protein signaling 2 with hypertension in the general Xinjiang Kazakh population.Semantic proximity Read ↗

Pharmacogenomics of G protein-coupled receptor signaling: insights from health and disease.Semantic proximity Read ↗

Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice.Semantic proximity Read ↗

Reduced expression of regulator of G-protein signaling 2 (RGS2) in hypertensive patients increases calcium mobilization and ERK1/2 phosphorylation induced by angiotensin II.Semantic proximity Read ↗

N-terminal residues control proteasomal degradation of RGS2, RGS4, and RGS5 in human embryonic kidney 293 cells.Semantic proximity Read ↗

G proteins and hypertension: an alternative candidate gene approach.Semantic proximity Read ↗

Are RGS2 gene polymorphisms associated with high blood pressure in an ethnicity- and gender-specific manner?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.