Article
The zinc-finger protein CNBP is required for forebrain formation in the mouse.
Development (Cambridge, England) - 1 Apr 2003
Chen Wei, Liang Yuqiong, Deng Wenjie, Shimizu Ken, Ashique Amir M, Li En, Li Yi-Ping
Abstract excerpt
Mouse mutants have allowed us to gain significant insight into axis development. However, much remains to be learned about the cellular and molecular basis of early forebrain patterning. We describe a lethal mutation mouse strain generated using promoter-trap mutagenesis. The mutants exhibit severe forebrain truncation in homozygous mouse embryos and various craniofacial defects in heterozygotes. We show that the...
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