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Article

Sf3b4-depleted Xenopus embryos: A model to study the pathogenesis of craniofacial defects in Nager syndrome.

Developmental biology - 15 Jul 2016

Devotta Arun, Juraver-Geslin Hugo, Gonzalez Jose Antonio, Hong Chang-Soo, Saint-Jeannet Jean-Pierre

Abstract excerpt

Mandibulofacial dysostosis (MFD) is a human developmental disorder characterized by defects of the facial bones. It is the second most frequent craniofacial malformation after cleft lip and palate. Nager syndrome combines many features of MFD with a variety of limb defects. Mutations in SF3B4 (splicing factor 3b, subunit 4) gene, which encodes a component of the pre-mRNA spliceosomal complex, were recently...

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Identifiers

PMID: 26874011
DOI: 10.1016/j.ydbio.2016.02.010
PMCID: PMC4914463

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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