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Article

Proteolytic cleavage of Trop2 at Arg87 is mediated by matriptase and regulated by Val194.

FEBS letters - 1 Oct 2020

Kamble Pradnya R, Rane Sanjana, Breed Ananya A, Joseph Shaini, Mahale Smita D, Pathak Bhakti R

Abstract excerpt

Proteolytic processing is an important post-translational modification affecting protein activity and stability. In the current study, we investigate the N-terminal cleavage of Trop2, a protein which is overexpressed in many cancers. We demonstrate that Trop2 is cleaved at Arg87 by a transmembrane serine protease, matriptase. Homology modeling and site-directed mutagenesis of amino acids in close proximity to the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32761920
DOI: 10.1002/1873-3468.13899

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