Article
Mutation at the processing site of chicken low density lipoprotein receptor-related protein impairs efficient endoplasmic reticulum exit, but proteolytic cleavage is not essential for its endocytic functions.
The Journal of biological chemistry - 23 Oct 1998
Ko K W, McLeod R S, Avramoglu R K, Nimpf J, FitzGerald D J, Vukmirica J, Yao Z
Abstract excerpt
The low density lipoprotein receptor-related protein (LRP) is synthesized as a proreceptor that undergoes post-translational proteolytic processing, yielding a noncovalently associated alphabeta dimer as the mature LRP. We tested the role of processing by creating a mutant in which the P1 residue...
Topics
- Animals
- Arginine
- Biological Transport
- Chickens
- Endocytosis
- Endoplasmic Reticulum
- Furin
- Low Density Lipoprotein Receptor-Related Protein-1
- Mutation
- Protein Processing, Post-Translational
- Receptors, Immunologic
- Recombinant Proteins
- Subtilisins