Article
Mutation at the processing site of chicken low density lipoprotein receptor-related protein impairs efficient endoplasmic reticulum exit, but proteolytic cleavage is not essential for its endocytic functions.
The Journal of biological chemistry - 23 Oct 1998
Ko K W, McLeod R S, Avramoglu R K, Nimpf J, FitzGerald D J, Vukmirica J, Yao Z
Abstract excerpt
The low density lipoprotein receptor-related protein (LRP) is synthesized as a proreceptor that undergoes post-translational proteolytic processing, yielding a noncovalently associated alphabeta dimer as the mature LRP. We tested the role of processing by creating a mutant in which the P1 residue (Arg3942) of the consensus site for furin cleavage (Arg-Asn-Arg-Arg3942 downward arrow) was replaced with Ser in...
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