Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ectodomain shedding of TβRIII is required for TβRIII-mediated suppression of TGF-β signaling and breast cancer migration and invasion.

Molecular biology of the cell - 15 Aug 2014

Elderbroom Jennifer L, Huang Jennifer J, Gatza Catherine E, Chen Jian, How Tam, Starr Mark, Nixon Andrew B, Blobe Gerard C

Abstract excerpt

The type III transforming growth factor β (TGF-β) receptor (TβRIII), also known as betaglycan, is the most abundantly expressed TGF-β receptor. TβRIII suppresses breast cancer progression by inhibiting migration, invasion, metastasis, and angiogenesis. TβRIII binds TGF-β ligands, with membrane-bound TβRIII presenting ligand to enhance TGF-β signaling. However, TβRIII can also undergo ectodomain shedding,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast Neoplasms
Share to Cell Movement

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Progression

Share to Gene Expression Regulation, Neoplastic

Share to Mice, Nude

Share to Proteoglycans

Share to Receptors, Transforming Growth Factor beta

Share to Transforming Growth Factor beta3

Source

Open in PubMed Open full text

Identifiers

PMID: 24966170
DOI: 10.1091/mbc.E13-09-0524
PMCID: PMC4142606

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ectodomain shedding of TβRIII is required for TβRIII-mediated suppression of TGF-β signaling and breast cancer migration and invasion.PMID 24966170Read ↗

The balance of cell surface and soluble type III TGF-β receptor regulates BMP signaling in normal and cancerous mammary epithelial cells.Semantic proximity Read ↗

TβRIII suppresses non-small cell lung cancer invasiveness and tumorigenicitySemantic proximity Read ↗

Heparan sulfate modifications of betaglycan promote TIMP3-dependent ectodomain shedding to fine-tune TGF-β signalingSemantic proximity Read ↗

Expression of the type III TGF-β receptor is negatively regulated by TGF-βSemantic proximity Read ↗

A novel splice variant of human TGF-β type II receptor encodes a soluble protein and its Fc-tagged version prevents liver fibrosis <i>in vivo</i>Semantic proximity Read ↗

Role of TGF-β receptor III localization in polarity and breast cancer progressionSemantic proximity Read ↗

A novel gain-of-function mutation of TGF-β receptor II promotes cancer progression via delayed receptor internalization in oral squamous cell carcinoma.Semantic proximity Read ↗

A dual prognostic role for the TGFβ receptors in human breast cancer.Semantic proximity Read ↗

Type III TGF-β Receptor Enhances Colon Cancer Cell Migration and Anchorage-Independent GrowthSemantic proximity Read ↗

Kindlin-2 regulates the oncogenic activities of integrins and TGF-β in triple-negative breast cancer progression and metastasisSemantic proximity Read ↗

Three key residues underlie the differential affinity of the TGFbeta isoforms for the TGFbeta type II receptor.Semantic proximity Read ↗

In the absence of type III receptor, the transforming growth factor (TGF)-beta type II-B receptor requires the type I receptor to bind TGF-beta2.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.