Article
The Caenorhabditis elegans mRNA 5'-capping enzyme. In vitro and in vivo characterization.
The Journal of biological chemistry - 18 Apr 2003
Takagi Toshimitsu, Walker Amy K, Sawa Chika, Diehn Felix, Takase Yasutaka, Blackwell T Keith, Buratowski Stephen
Abstract excerpt
Eukaryotic mRNA capping enzymes are bifunctional, carrying both RNA triphosphatase (RTPase) and guanylyltransferase (GTase) activities. The Caenorhabditis elegans CEL-1 capping enzyme consists of an N-terminal region with RTPase activity and a C-terminal region that resembles known GTases, However, CEL-1 has not previously been shown to have GTase activity. Cloning of the cel-1 cDNA shows that the full-length...
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