Article
Conditional inactivation of mRNA capping enzyme affects yeast pre-mRNA splicing in vivo.
RNA (New York, N.Y.) - 1 Jun 1996
Schwer B, Shuman S
Abstract excerpt
Acquisition of the 5'cap is the earliest modification event during eukaryotic mRNA synthesis. The cap is thought to facilitate later processing steps, such as pre-mRNA splicing. If this is so, then a defect in cap synthesis should impact on splicing in vivo. We tested this hypothesis by examining the consequences of conditional inactivation of the Saccharomyces cerevisiae CEG1 gene, which encodes mRNA...
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